Three U.S. service members were killed in action and five seriously wounded, Central Command said, the first reported U.S. casualties in the joint attack with Israel.

U.S. forces say they have hit 1,000 targets over the past two days in a race to take out Iran’s ability to threaten American personnel and allies across the Middle East.

Iran’s constitution calls for an assembly of experts to choose the next supreme leader, but that may not be possible in wartime.

Ayatollah Ali Khamenei was killed in an Israeli airstrike on his Tehran compound, according to four Israeli security officials briefed on the matter.

Satellite images and videos reveal dozens of targets of strikes on Iran, including the Tehran compound of Iran’s supreme leader, Ayatollah Ali Khamenei. Iran has hit at least one U.S. base in the region.

Iran’s ambassador to the United Nations said the strike killed more than 100 children at the girls’ elementary school in southern Iran.

He played a behind-the-scenes role in Iran’s Islamic revolution, served as president in the 1980s and dominated the country for more than three decades.